InterSpace®
InterSpace®: Trust the Science.
More than 20 years as your proven infection remedy.
InterSpace®: Trust the Science.
More than 20 years as your proven infection remedy.
Infection to Correction.
The most widely studied spacer technology in the world, InterSpace® is the first pre-formed spacer with 93.8 percent eradication rate.1 Its positive clinical results coupled with the systematic research of surgeon-made devices led to the design of products that could be both mechanically safe and pharmacologically effective.
InterSpace Knee, Hip and Shoulder are preformed, articulating, partial load-bearing structures comprised of gentamicin-impregnated PMMA bone cement. InterSpace is indicated for skeletally-mature patients undergoing the first stage of a two-stage revision arthroplasty.
The spacer’s textured finish increases its surface area, which allows for greater antibiotic release.
Features and Benefits
- Proven high release formulation and design yields predictable and consistent local antimicrobial activity compared to other treatment options.1-3
- Maintains joint space and allows limited mobility with partial weight bearing1*
- Stabilizes or tensions the soft tissues and reduces bone loss between stages, potentially facilitating easier re-implantation during a second-stage procedure4-7
- InterSpace demonstrates functional success rates equivalent to non-infected revisions8
- Shortens operating time1,4
- Stainless steel reinforcing core in Hip and Shoulder Spacers
- Multiple sizing options
0
Cases Reported9
0%
Eradication rate at latest follow-up9
0
Peer-reviewed papers at 18 different sites9
0
Months average follow-up9
Clinical Data
InterSpace® shows its reliability, efficiency and effectiveness when treating joint sepsis with global compilation of clinical evidence from more than 19 peer-reviewed papers from 18 different sites.9
Study Criteria and Outcomes
The inclusion criteria removed case reports, clinical series with less than 10 patients, duplicate studies and series with a mean follow-up of less than 24 months. The exclusion criteria left 19 papers for a total of 732 spacers at 18 centers.
Only 43 patients (5.9%) had persistent infection that required a spacer exchange or resection arthroplasty
Seven hundred and nine (709) patients underwent the second-stage procedure, of the 709, only 44 patients (6.2%) had an infection at the mean follow-up of 55 months.
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InterSpace® Hip
InterSpace Hip is designed to temporarily replace a Total Hip Arthroplasty (THA) that has been explanted due to infection.
InterSpace® Tapered Wedge
The InterSpace Tapered Wedge allows surgeons to more conservatively treat patients following a peri-prosthetic joint infection (PJI) of a wedge-style stem.
This modern tapered wedge design helps to more conservatively address a narrow femoral cavity, and the low profile lateral shoulder allows for ease of insertion when implanting the stem.
InterSpace® Knee
InterSpace Knee is designed to temporarily replace an infected implant during a Total Knee Arthroplasty (TKA) and provide the patient with mobility and predictable, consistent local antibiotic release.1,3
To complement our existing knee spacer, we now offer an augmented tibial stem (ATS), which comes in multiple size and thickness options to best fit patient anatomy without sacrificing the stem length.
InterSpace® Shoulder
InterSpace Shoulder is designed to temporarily replace an infected implant during a Total Shoulder Arthroplasty (TSA) and provide the patient with mobility and predictable, consistent local antibiotic release.1,3
Resources
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InterSpace® is produced by Tecres® S.p.A., Italy, and distributed in the United States exclusively by Exactech, Inc.
References
References
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- Romano CL, et al. Two-stage revision surgery with preformed spacers and cementless implants for septic hip arthritis: a prospective, non-randomized cohort study. BMC Infect Dis. 2011 May 16;11:129. doi: 10.1186/1471-2334-11-129.
- Pattyn C, et al. Preformed gentamicin spacers in two-stage revision hip arthroplasty: functional results and complications. Int Orthop. 2011 Oct;35(10):1471-6. doi: 10.1007/s00264-010-1172-8. Epub 2010 Nov 30.
- Burnett S, et al. Technique and timing of two-stage exchange for infection in TKA. Clin Orthop Relat Res. 2007 Nov;464:164-78.
- Castelli C, et al. Key points in two-stage revision for infected knee arthroplasty: bone loss, quality of life between stages and surgical approach at second stage. In: Meani E, et al [ed]. Infection and local treatment in orthopedic surgery. Berlin: Springer-Verlag; 2007. 294-301.
- Diefenbeck M, et al. Prophylaxis and treatment of implant-related infections by local application of antibiotics. 2006 May;37 Suppl 2:S95-104. Review.
- Romano CL, et al. Aseptic versus septic total hip arthroplasty revision: comparing the results. Poster presented at the 76th Annual American Academy of Orthopaedic Surgeons Meeting; 2009 Feb 25-28; Las Vegas, NV.
- Soffiatti R. The preformed spacers: from the idea to the realization of an industrial device. In: Meani E, et al [ed].Infection and local treatment in Orthopedic surgery. Berlin: Springer-Verlag; 2007. 201-4.
- Bertazzoni Minelli E, et al. Release of gentamicin and vancomycin from temporary human hip spacers in two stage revision of infected arthroplasty. J Antimicrob Chemother. 2004 Feb;53(2):329-34. E pub 2003 Dec 19.
- Data on file at Exactech, Inc.