InterSpace Knee, Hip and Shoulder are preformed, articulating, partial load-bearing structures comprised of gentamicin-impregnated PMMA bone cement. InterSpace is indicated for skeletally-mature patients undergoing the first stage of a two-stage revision arthroplasty.
The spacer’s textured finish increases its surface area, which allows for greater antibiotic release.
Proven high release formulation and design yields predictable and consistent local antimicrobial activity compared to other treatment options2-4
Maintains joint space and allows limited mobility with partial weight-bearing2,5,6*
Stabilizes or tensions the soft tissues and reduces bone loss between stages, potentially facilitating easier re-implantation during a second-stage procedure6-8
Shortens operating time2
Demonstrates functional success rates equivalent to non-infected revisions9
Improves quality of life between procedures6
Stainless steel reinforcing core in Hip and Shoulder Spacers
Multiple sizing options
Eradication rate at latest follow-up1
Peer-reviewed papers at 22 different sites1
Months average follow-up1
Study Criteria and Outcomes
The inclusion criteria removed case reports, clinical series with less than 10 patients, duplicate studies and series with a mean follow-up of less than 24 months. The exclusion criteria left 24 papers for a total of 1,024 spacers at 22 centers.
Infection Control at Spacer Removal94%
Only 57 patients (5.6%) had persistent infection that required a spacer exchange or resection arthroplasty
Eradication Rate at Latest Follow-up94%
1,024 patients underwent the second-stage procedure, of the 1,024, only 57 patients (5.6%) had an infection at the mean follow-up of 57.6 months.
InterSpace® Tapered Wedge
The InterSpace Tapered Wedge allows surgeons to more conservatively treat patients following a peri-prosthetic joint infection (PJI) of a wedge-style stem and this modern tapered wedge design helps to more conservatively address a narrow femoral cavity. The lower profile lateral shoulder allows for ease of insertion when implanting the stem.
1. Data on file at Exactech, Inc.
2. Coffey MJ, et al. Treatment of glenohumeral sepsis with a commercially produced antibiotic-impregnated cement spacer. J Shoulder Elbow Surg. 2010 Sep;19(6):868-73.
3. Mutimer J, et al. Measurements of in vivo intra-articular gentamicin levels from antibiotic loaded articulating spacers in revision total knee replacement. Knee. 2009 Jan;16(1):39-41.
4. Soffiatti R. The Preformed Spacers: From the idea to the realization of an industrial device. In: Meani E, et al [ed]. Infection and local treatment in Orthopedic surgery. Berlin: Springer-Verlag. 2007;201-4.
5. Romanò CL, et al. Preformed antibiotic-loaded cement spacers for two-stage revision of infected total hip arthroplasty. Long-term results. Hip Int. 2012 Jul-Aug;22 Suppl 8:S46-53.
6. Castelli CC, et al. Two-stage treatment of infected total knee arthroplasty: two to thirteen year experience using an articulating preformed spacer. Int Orthop. 2014 Feb;38(2):405-12.
7. Magnan B, et al. Two-stage revision of infected total hip replacement using a pre-formed, \\antibiotic-loaded acrylic cement spacer. In: Meani E, et al [ed]. Infection and local treatment in orthopedic surgery. Berlin: Springer-Verlag; 2007. 205-13.
8. Vecchini E, et al. Antibiotic-Loaded Spacer for Two-Stage Revision of Infected Total Knee Arthroplasty. J Knee Surg. 2017 Mar;30(3):231-237.
9. Romanò CL, et al. Septic versus aseptic hip revision: how different? J Orthop Traumatol. 2010;11(3):167-174. doi:10.1007/s10195-010-0106-y.
*Partial weight-bearing must be assessed on an individual basis with relation to the anatomic condition of the local bone, bone quality and clinical conditions of the patient during rehabilitation stages. Care must be taken to minimize the risk of damaging bone tissue and the implant through excessive weight-bearing or forced mobilization.
InterSpace® is produced by Tecres® S.p.A., Italy, and distributed in the United States exclusively by Exactech, Inc.