InterSpace®
InterSpace®: Trust the Science.
More than 20 years as your proven infection remedy.
InterSpace®: Trust the Science.
More than 20 years as your proven infection remedy.
Infection to Correction.
The most widely studied spacer technology in the world, InterSpace® is the first pre-formed spacer with 93.8 percent eradication rate.1 Its positive clinical results coupled with the systematic research of surgeon-made devices led to the design of products that could be both mechanically safe and pharmacologically effective.
InterSpace Knee, Hip and Shoulder are preformed, articulating, partial load-bearing structures comprised of gentamicin-impregnated PMMA bone cement. InterSpace is indicated for skeletally-mature patients undergoing the first stage of a two-stage revision arthroplasty.
The spacer’s textured finish increases its surface area, which allows for greater antibiotic release.
Features and Benefits
- Proven high release formulation and design yields predictable and consistent local antimicrobial activity compared to other treatment options.1-3
- Maintains joint space and allows limited mobility with partial weight bearing1*
- Stabilizes or tensions the soft tissues and reduces bone loss between stages, potentially facilitating easier re-implantation during a second-stage procedure4-7
- InterSpace demonstrates functional success rates equivalent to non-infected revisions8
- Shortens operating time1,4
- Stainless steel reinforcing core in Hip and Shoulder Spacers
- Multiple sizing options
0
Cases Reported9
0%
Eradication rate at latest follow-up9
0
Peer-reviewed papers at 18 different sites9
0
Months average follow-up9
Clinical Data
InterSpace® shows its reliability, efficiency and effectiveness when treating joint sepsis with global compilation of clinical evidence from more than 19 peer-reviewed papers from 18 different sites.9
Study Criteria and Outcomes
The inclusion criteria removed case reports, clinical series with less than 10 patients, duplicate studies and series with a mean follow-up of less than 24 months. The exclusion criteria left 19 papers for a total of 732 spacers at 18 centers.
Only 43 patients (5.9%) had persistent infection that required a spacer exchange or resection arthroplasty
Seven hundred and nine (709) patients underwent the second-stage procedure, of the 709, only 44 patients (6.2%) had an infection at the mean follow-up of 55 months.
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InterSpace® Hip
InterSpace Hip is designed to temporarily replace a Total Hip Arthroplasty (THA) that has been explanted due to infection.
InterSpace® Tapered Wedge
As the newest addition to the Exactech Spacer family, the InterSpace Tapered Wedge allows surgeons to more conservatively treat patients following a peri-prosthetic joint infection (PJI) of a wedge-style stem.
This modern tapered wedge design helps to more conservatively address a narrow femoral cavity, and the low profile lateral shoulder allows for ease of insertion when implanting the stem.
InterSpace® Knee
InterSpace Knee is designed to temporarily replace an infected implant during a Total Knee Arthroplasty (TKA) and provide the patient with mobility and predictable, consistent local antibiotic release.1,3
InterSpace® Shoulder
InterSpace Shoulder is designed to temporarily replace an infected implant during a Total Shoulder Arthroplasty (TSA) and provide the patient with mobility and predictable, consistent local antibiotic release.1,3
Resources
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InterSpace® is produced by Tecres® S.p.A., Italy, and distributed in the United States exclusively by Exactech, Inc.
References
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- Romano CL, et al. Two-stage revision surgery with preformed spacers and cementless implants for septic hip arthritis: a prospective, non-randomized cohort study. BMC Infect Dis. 2011 May 16;11:129. doi: 10.1186/1471-2334-11-129.
- Pattyn C, et al. Preformed gentamicin spacers in two-stage revision hip arthroplasty: functional results and complications. Int Orthop. 2011 Oct;35(10):1471-6. doi: 10.1007/s00264-010-1172-8. Epub 2010 Nov 30.
- Burnett S, et al. Technique and timing of two-stage exchange for infection in TKA. Clin Orthop Relat Res. 2007 Nov;464:164-78.
- Castelli C, et al. Key points in two-stage revision for infected knee arthroplasty: bone loss, quality of life between stages and surgical approach at second stage. In: Meani E, et al [ed]. Infection and local treatment in orthopedic surgery. Berlin: Springer-Verlag; 2007. 294-301.
- Diefenbeck M, et al. Prophylaxis and treatment of implant-related infections by local application of antibiotics. 2006 May;37 Suppl 2:S95-104. Review.
- Romano CL, et al. Aseptic versus septic total hip arthroplasty revision: comparing the results. Poster presented at the 76th Annual American Academy of Orthopaedic Surgeons Meeting; 2009 Feb 25-28; Las Vegas, NV.
- Soffiatti R. The preformed spacers: from the idea to the realization of an industrial device. In: Meani E, et al [ed].Infection and local treatment in Orthopedic surgery. Berlin: Springer-Verlag; 2007. 201-4.
- Bertazzoni Minelli E, et al. Release of gentamicin and vancomycin from temporary human hip spacers in two stage revision of infected arthroplasty. J Antimicrob Chemother. 2004 Feb;53(2):329-34. E pub 2003 Dec 19.
- Data on file at Exactech, Inc.