Features & Benefits

Features and Benefits

Inert Biological Carrier Matrix

• Thermoplastic. Formable into any shape at 45°C
• A resilient solid at body temperature
• Insoluble in aqueous fluids at 39°C
• Inert biological carrier used in surgery since 1952¹
  

Demineralized Bone Matrix (DBM)

• Also known as demineralized freeze-dried bone allograft (DFDBA)
• Optimal concentration of DBM for osteoinductivity¹
• Donor osteoinductivity verified 100%*
• Osteogenic property of demineralized bone matrix was first demonstrated in 1965²

Cortical Cancellous Bone Chips

• Contains greater than 95% compacted bone chips by volume
• Precisely sized and shaped for filling defects 1-2mm in size
• Osteoconductive
• Cortical cancellous bone chips have been used in surgery since 1947³
• Minerals retained

Critical Components

By optimizing the concentration of osteoinductive demineralized bone matrix (DBM), Regenaform and Regenafil provide the foundation for bone regeneration.⁴ The inert biological carrier matrix allows revascularzation to occur, making it an ideal carrier for DBM.⁵ Regenaform adds a third component, mineralized cortical cancellous bone chips (CCC), which provides the constituents necessary for osteoconduction.⁴

Clinical Use

These grafts have been used in the following procedures:

Ridge augmentations; Onlay grafting; Sinus elevations; Socket/ridge preservation with compromised osseous support; In conjunction with dental implant placement.

References

1. Wironen J.F. et al., Effect of bone protein and carrier matrices on BMPstimulated osteogenesis. Transactions of the 44th Annual Meeting. Orthopaedic Research Society, 23:2, p. 603, 1998.
2. Urist M.R., Bone: Formation by Autoinduction. Science, 1965. 150(3698): pp. 893-899.
3. Chase S.W. and C.H. Herndon, The fate of autegenous and homogenous bone grafts: A historical review. Journal of Bone and Joint Surgery, 1955. 37-A(4): pp. 809-841.
4. Goldberg V., et al., Biology of autografts and allografts. In Bone and Cartilage Allografts: Biology and Clinical Applications. Edited by V. Goldberg and G. Friedlaender. Park Ridge, IL, American Academy of
Orthopaedic Surgeons, 1989, p. 3.
5. Gellad FE, Sadato N, Numaguchi Y, Levine AM. Vascular metastatic lesions of the spine: pre-operative embolization. Radiology. 176: 683-6, 1990.

Additional Reading
King C., et al., Effectiveness of Regenafil in Treating Intrabony Pockets–6 Month Results. IADR, March 2002.

*Finished product induced bone formation when implanted in a modified athymic nude rat assay. Findings from an animal model are not necessarily predictive of human clinical results.