Features & Benefits

Inert Biological Carrier Matrix

• Thermoplastic – formable into any shape at 45°C
• A resilient solid at body temperature
• Inert biological carrier used in surgery since 1952¹
• Biocompatible
• Will not wash away during irrigation
  

Demineralized Bone Matrix (DBM)

• Also known as demineralized freeze-dried bone allograft (DFDBA)
• Optimal concentration of DBM for osteoinductivity²
• Osteoinductivity verified 100 percent by lot
• Osteogenic property of demineralized bone matrix was first demonstrated in 1965³
• Room Temperature Regenaform contains 60 percent DBM by weight

Cortical Cancellous Bone Chips

• Contains greater than 95 percent compacted bone chips by volume
• Precisely sized and shaped for filling defects
  
• Osteoconductive⁴
• Cortical cancellous bone chips have been used in surgery since 1947³
• Minerals retained

Critical Components

By optimizing the concentration of osteoinductive demineralized bone matrix (DBM), Regenaform® and Regenafil® provide the foundation for bone regeneration.⁴ The inert biological carrier matrix allows revascularzation to occur, making it an ideal carrier for DBM.⁵ Regenaform adds a third component, mineralized cortical cancellous bone chips (CCC), which provides the constituents necessary for osteoconduction.⁴

Clinical Use

Regenaform would typically by used in regenerative sites that necessitate augmentation, elevation or preservation.

References

1. Jaw R, Silveria E, Yonchek J, Kirk J, Nataraj C. Comparative Analysis of Osteoinductivity Testing Methods. Pittsburgh Bone Symposium, Pittsburgh PA: 523-536, 2003.

2. Wironen JF, et al. Effect of bone protein and carrier matrices on BMP-stimulated osteogenesis. Transactions of the 44th Annual Meeting of the Orthopaedic Research Society. 1998, 23:2; 603.

3. Chase SW, CH Herndon. The fate of autogenous and homogenous bone grafts. J Bone and Joint Surg Am. 1955 Jul;37-A(4):809-41.

4. Friedlaender GE, Goldberg VM (eds). Bone and Cartilage Allografts: Biology and Clinical Application. Park Ridge, IL: American Academy of Orthopaedic Surgeons, 1991.

5. Gellad FE, Sadato N, Numaguchi Y, Levine AM. Vascular metastatic lesions of the spine: pre-operative embolization. Radiology. 1990 Sep;176(3):683-6.

Additional Reading
King C, et al. Effectiveness of Regenafil in Treating Intrabony Pockets–6 Month Results. IADR, March 2002.