Inert Biological Carrier Matrix

• Thermoplastic – formable into any shape at 45°C
• A resilient solid at body temperature
• Inert biological carrier used in surgery since 1952¹
• Biocompatible
• Will not wash away during irrigation
  

Demineralized Bone Matrix (DBM)

• Also known as demineralized freeze-dried bone allograft (DFDBA)
• Optimal concentration of DBM for osteoinductivity²
• Osteoinductivity verified 100 percent by lot
• Osteogenic property of demineralized bone matrix was first demonstrated in 1965³
• Room Temperature Regenafil contains 60 percent DBM by weight

Critical Components

By optimizing the concentration of osteoinductive* demineralized bone matrix (DBM), Regenaform® and Regenafil® provide the foundation for bone regeneration.⁴ 

Clinical Use

Regenafil would be typically used in regenerative sites for defects, preservation and resection procedures (contained wall procedures).

Product Application

References

1. Jaw R, Silveria E, Yonchek J, Kirk J, Nataraj C. Comparative Analysis of Osteoinductivity Testing Methods. Pittsburgh Bone Symposium, Pittsburgh PA: 523-536, 2003.

2. Wironen JF, et al. Effect of bone protein and carrier matrices on BMP-stimulated osteogenesis. Transactions of the 44th Annual Meeting of the Orthopaedic Research Society. 1998, 23:2; 603.

3. Chase SW, CH Herndon. The fate of autogenous and homogenous bone grafts. J Bone Joint Surg Am. 1955 Jul;37-A(4):809-41.

4. Friedlaender GE, Goldberg VM (eds). Bone and Cartilage Allografts: Biology and Clinical Application. Park Ridge, IL: American Academy of Orthopaedic Surgeons, 1991.

Additional Reading
King C. et al. Effectiveness of Regenafil in Treating Intrabony Pockets–6 Month Results. IADR, March 2002.