Simple Predictable Regeneration

Exactech is shaping the future of bone repair with Regenaform^® and Regenafil^® allograft. For almost a decade, Exactech has been a leader in orthopaedic bone regeneration. Now, these materials are offering simple and predictable results to dental professionals.

Clinically shown to induce bone formation for a variety of applications, Regenaform and Regenafil are the natural choices for biological bone repair.  Regenaform would typically be used in regenerative sites that necessitate augmentation, elevation or preservation.  Regenafil would be typically used in regenerative sites for defects, preservation and resection procedures (contained wall procedures).

Regenafil and Regenaform products ensure the overall quality and regeneration you’ve come to expect in our bone paste products

Simple

Regenaform and Regenafil Allograft Pastes are available in two prepackaged modalities–Room Temperature and Frozen–to meet your personal preference.

When warmed, Regenaform and Regenafil Frozen become soft and moldable yet return to a resilient solid at body and room temperature. Simply shape and fit it into the site; the materials adapt to the defect morphology.

Regenaform and Regenafil Room Temperature (RT) can be hydrated chairside with a variety of diluents and are available for use within 60 seconds. This eliminates the need for a water bath and freezer.

Regenaform and Regenafil are available in a wide range of sizes. This maximizes the precious gift of human tissue by reducing waste. Whether you use Regenaform and Regenafil Frozen or Room Temperature, they both offer the advantage of exceptional handling and stability at the graft site.

Predictable Regeneration

Both Regenaform and Regenafil contain demineralized bone matrix (DBM), also known as DFDBA (demineralized freeze-dried bone allograft), which, through osteoinduction provides for the formation and development of bony tissue.¹ Regenaform also contains non-demineralized cortical cancellous bone chips, which provide for osteoconductivity.²

DBM from each donor is implanted in a scientifically-proven in vivo rat model to confirm osteoinductivity (Urist’s model). Only DBM that is demonstrated by histology to meet osteoinductive standards after sterilization is used. Regenaform and Regenafil have been clinically shown to induce bone formation and facilitate bone growth. By employing the in vivo assay and a rigorous subsequent histological screening, Regenafil and Regenaform products ensure the overall quality and regeneration you’ve come to expect in our bone paste products.³

References

1. Urist M.R. Bone: Formation by Autoinduction. Science, 1965. 150(3698): pp. 893-899.

2. Goldberg V., et al., Biology of autografts and allografts. In Bone and Cartilage Allografts: Biology and Clinical Applications. Edited by V. Goldberg and G. Friedlaender. Park Ridge, IL, American Academy of Orthopaedic Surgeons, 1989, p. 3.

3. Jaw R, Silveria E, Yonchek J, Kirk J, Nataraj C. Comparative Analysis of Osteoinductivity Testing Methods. Pittsburgh Bone Symposium, Pittsburgh PA: 523-536, 2003